Lymphomatoid Papulosis

Key Points
Rare skin condition which typically affects the trunk and limbs
Initially consists of raised bumps accompanied by mild itching, which develop into blisters and sores during the healing process

Lymphomatoid papulosis is a very rare skin condition which typically affects the back, chest, stomach, and limbs. Initially consisting of raised bumps accompanied by mild itching, lesions develop central necrosis. Later ulceration and crusting before healing completely, which occurs within 2-8 weeks of their initial appearance. Lesions usually heal without scarring.

The cause of lymphomatoid papulosis is unknown, but it is associated with the development of CD30 positive T-lymphocytes. It may develop in anyone regardless of gender, age or ethnic group, and a small number of cases may be associated with past or present diagnosis of lymphoma. Currently it is estimated that 10-20% of patients with Lymphomatoid papulosis eventually develop lymphoma.

Differential Diagnosis (Other conditions with similar appearance)
Cutaneous CD30+ (Ki-1) Anaplastic Large-Cell Lymphoma
Lymphocytoma Cutis
Cutaneous T-Cell Lymphoma
Folliculitis
Insect Bites
Scabies
Langerhans Cell Histiocytosis
Leukemia Cutis

Diagnosis
Key Points
Diagnosis is based on skin biopsy
Biopsies may be repeated to detect associated conditions or complications

Diagnosis of lymphomatoid papulosis is based on a skin biopsy of the affected area. Such tests may be repeated to detect the development of associated conditions or complications, such as lymphoma.

Treatment
No cure exists
Goal of treatment is the control and reduce symptoms

No cure for lymphomatoid papulosis exists. The goal of treatment is to assist existing lesions in the healing process and to control the formation of new lesions. Therapies recommended may include the use of topical steroids, phototherapy, and methotrexate. Additionally, affected persons should be persistently reevaluated to detect associated conditions or complications as early as possible.