*Rare type of pemphigus, typically affecting the torso first, then spreading to the face and/or scalp
*Autoimmune disorder which destroys connectivity of skin cells
*Consists of small easily ruptured blisters which leave behind erosions, crusting, and inflammation
Pemphigus foliaceus is a rare type of pemphigus which typically affects the torso first and spreads to the face and/or scalp. The condition consists of the formation of small, easily ruptured blisters. Ruptured blisters leave behind skin erosions which may crust and become red and inflamed. This may be accompanied by burning or pain in the affected area.
Pemphigus foliaceus is an autoimmune disorder in which the immune system destroys the connective tissue that holds skin cells together, causing blistering. The condition may be provoked by exposure to sunlight. Additionally, the condition may result from certain medications, and an endemic form of the condition which is provoked by a viral infection is common in South America. The condition may affect any age, gender or ethnic group, but typically appears between 50-60 years of age.
Differential Diagnosis (Other conditions with similar appearance)
Drug-Induced Bullous Disorders
Pemphigus (various forms)
Epidermolysis bullosa Acquisita
Subcorneal pustular dermatosis
Linear IgA dermatosis
*Diagnosis based on skin biopsy of the affected area
*Staining will be performed to confirm the condition
Pemphigus foliaceus is typically diagnosed based on a skin biopsy of the affected area, and confirmed by a stain of the affected tissue. These tests will also rule out similar appearing conditions.
*Condition may resolve spontaneously in some cases, and persist in others
*Goal of treatment is to prevent further involvement and resolve established lesions
*Treatment typically consists of topical corticosteroids and antibiotic medications
Pemphigus foliaceus may resolve spontaneously in some cases, but is often persistent. The goal of treatment is to prevent further involvement and to resolve established lesions. Treatment of the condition typically consists of the application of topical corticosteroids in conjunction with antibiotic medications. In severe cases, more aggressive treatments may be required.